The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells
ABSTRACT Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island.These genotoxic metabolites are produced by honeywell pa404a1009 pks-encoded peptide-polyketide synthases as inactive prodrugs called precolibactins, which are then conve